Millions of Britons regularly reaching for paracetamol could be putting themselves at serious risk, according to alarming new research from the University of Edinburgh. The study suggests that long-term use of this common painkiller may significantly increase the risk of heart attacks and strokes in people with high blood pressure.
Researchers discovered that patients with hypertension who took paracetamol regularly saw their blood pressure rise dramatically compared to those taking a placebo. This elevation in blood pressure could potentially increase cardiovascular risk by up to 20%, presenting a serious concern for the estimated one-third of UK adults living with high blood pressure.
What the research revealed
The comprehensive study followed 110 volunteers with a history of high blood pressure over two weeks. Participants were divided into two groups: one received 1g of paracetamol four times daily (the maximum recommended dose), while the other received a placebo.
The results were striking. Those taking paracetamol experienced a significant increase in both systolic and diastolic blood pressure compared to the placebo group. This effect mirrors the blood pressure increase typically associated with non-steroidal anti-inflammatory drugs (NSAIDs), which doctors have long advised hypertension patients to avoid.
Expert medical opinion
Lead researcher Dr. Iain MacIntyre, Consultant Clinical Pharmacologist and Nephrologist at NHS Lothian, emphasised the importance of these findings: "This is not about short-term use of paracetamol for headaches or fever. We're talking about people who take it regularly for chronic pain, often at the maximum recommended dose."
Professor James Dear, Personal Chair of Clinical Pharmacology at the University of Edinburgh, added: "This study clearly shows that paracetamol increases blood pressure in people with hypertension, which is one of the most important risk factors for heart attacks and strokes."
Recommendations for patients
Medical experts stress that patients should not stop taking paracetamol without consulting their GP, especially if it has been prescribed for chronic pain management. However, they advise:
- Use the lowest effective dose for the shortest possible time
- Discuss alternative pain management strategies with your doctor
- Never exceed the maximum daily dose of 4g (eight 500mg tablets)
- Consider non-pharmacological approaches to pain management where appropriate
The researchers are calling for updated treatment guidelines to reflect these new findings, potentially reshaping how healthcare professionals approach pain management for patients with high blood pressure.
