ITV's resident doctor and NHS GP Dr Amir Khan has warned users of the widely prescribed medication omeprazole about potential side effects. The drug, commonly used to treat excess stomach acid, heartburn, acid reflux and stomach ulcers, belongs to a class of drugs known as proton pump inhibitors (PPIs). It works by reducing stomach acid, allowing damaged digestive tissue to heal.
In a recent Instagram video, Dr Khan highlighted three common side effects associated with long-term use of omeprazole. He explained that prolonged use can reduce the absorption of vitamin B12, magnesium and calcium, potentially leading to tiredness, nerve problems, mental fog, muscle spasms, irregular heartbeat, and weaker bones. He advised users to check their vitamin levels and ensure a diet rich in green leafy vegetables, nuts and dairy.
Dr Khan also warned of an increased risk of infections due to reduced stomach acid levels, which normally help eliminate harmful bacteria. This can raise the likelihood of contracting Clostridioides difficile (C.diff) infection, a severe intestinal condition causing extreme diarrhoea. Additionally, long-term use, particularly at high doses for a year or longer, has been associated with an increased risk of bone fractures in the hip, wrist or spine, as well as a higher probability of developing chronic kidney disease (CKD) and benign stomach growths called fundic gland polyps.
Dr Khan emphasised that patients should not stop their medication suddenly but should speak to their GP or pharmacist if they have concerns. He suggested that some patients may be able to reduce their dose or use the medication on and off, but only under medical supervision.
