Scientists have made a significant discovery in the blood of individuals suffering from long Covid, uncovering unusual biological changes that could explain the condition's persistent symptoms.
Abnormal Blood Clots and Immune Response
The research, reported on Monday 17 November 2025, identified two key abnormalities. The first is the presence of unusual microclots, which are abnormal clumps of blood-clotting proteins. The second involves alterations to the immune system, specifically with neutrophils forming filamentous structures known as NETs (Neutrophil Extracellular Traps).
Researchers propose that an interaction between these microclots and NETs could be the driving force behind the debilitating symptoms experienced by long Covid sufferers.
Significant Differences from Healthy Individuals
The study provided a clear comparison between patients and healthy controls. It revealed that long Covid patients had significantly higher levels of these microclots and NETs. Furthermore, the clots and structures found were also larger in size than those observed in people without the condition.
This finding, spearheaded by journalist Vishwam Sankaran, moves beyond merely documenting symptoms and provides a tangible, physiological explanation for the illness.
Implications for Future Treatment
This breakthrough is more than just an explanation; it opens a direct path towards developing new medical strategies. By identifying these specific blood markers, scientists can now work on creating targeted treatment strategies designed to address the root cause of the problem.
This brings a new sense of hope for the many people whose lives have been profoundly affected by long Covid, forcing some, as related reports highlight, to even quit the jobs they loved.
