Millions of people across the UK take bisoprolol, a beta-blocker used to treat heart and circulation problems. With over 32 million prescriptions issued in England alone in 2024-25, it is the seventh most prescribed drug in the country, according to NHS England. The medication helps prevent heart disease, heart attacks, and strokes, and is also used to treat angina, atrial fibrillation, and irregular heartbeat.
While common side effects such as dizziness, tiredness, cold hands or feet, and sleep difficulties affect more than one in 100 people, the NHS warns that these are usually mild and short-lived. However, there are rare but serious side effects that require immediate medical attention.
The NHS advises calling a doctor or NHS 111 if you experience shortness of breath with a cough that gets worse, wheezing or difficulty breathing, swelling of the ankles or feet, or an irregular heartbeat. More urgently, dial 999 if you have a serious allergic reaction (anaphylaxis), which may include difficulty breathing, swelling of the mouth, throat, or tongue, or a rash that is swollen, raised, itchy, blistered, or peeling.
Patients starting bisoprolol are advised to take the first dose at bedtime to minimise dizziness. The NHS stresses that if you experience any of these serious symptoms, do not drive yourself to A&E; instead, call 999 for advice on what to do.
