The unbeaten Dragons welcome an Ospreys side still looking for their first victory to Rodney Parade on Friday evening.
Filo Tiatia's side followed up an opening weekend draw away to Benetton with an impressive derby victory over the Scarlets in Newport last weekend. And the Men of Gwent will be looking for more derby delight as the Ospreys return to Welsh soil after two weeks in South Africa.
Ospreys' tough start
It has been a tricky start to the season for Mark Jones' men, going down to the Sharks and Lions in the first two weekends.
However, they are boosted by being able to name former Wallaby winger Marika Koroibete in their side for his Ospreys debut.
Kick-off and team news
Kick-off is at 7.45pm. You can also follow the match in the live blog below.
Dragons: Huw Anderson; Rio Dyer, Fetuli Paea, Aneurin Owen, Anzelo Tuitavuki; Tinus de Beer, Che Hope; Rodrigo Martinez, Elliot Dee, Robert Hunt, Seb Davies, Ben Carter (capt), Shane Lewis-Hughes, Harry Beddall, Harri Keddie.
Replacements: Brodie Coghlan, Rhodri Jones, Chris Coleman, Barny Langton-Cryer, Thomas Young, Rhodri Williams, Angus O'Brien, Fine Inisi.
Ospreys: Tom Rogers; Marika Koroibete, Evardi Boshoff, Keiran Williams, Keelan Giles; Dan Edwards, Kieran Hardy; Gareth Thomas, Sam Parry (capt), Tom Botha, Rhys Davies, Ryan Smith, Liam Wright, Ross Moriarty, Morgan Morris.
Replacements: Efan Daniel, Steffan Thomas, Rhys Henry, Lewis Jones, Morgan Morse, Reuben Morgan-Williams, Lawson Creighton, Lalakai Foketi.
Live updates
Welcome! It's time for another Welsh derby! The Dragons were victorious last weekend when the Scarlets rolled into Newport. But can the Ospreys mark their return to Welsh soil after their South African trip with a first win of the season? Stay tuned to find out.
