Kim Kardashian and Jennifer Aniston have both spoken publicly about receiving salmon sperm facials, sparking curiosity and questions about the procedure. The treatment, formally known as polynucleotide therapy, involves injecting or applying DNA fragments derived from salmon sperm into the skin.
Dr Richard Westreich, a facial plastic surgeon in New York City, explains that polynucleotides are small fragments of DNA and RNA. When introduced to the skin, they stimulate the production of new blood vessels, collagen, and keratinocytes, leading to a thicker, healthier, and more hydrated appearance. 'It's basically an overall skin boost,' he says.
The treatment has been available in Europe and Korea since around 2015, where it is typically injected. In the US, the FDA has not approved polynucleotides for injection, so providers often apply the formula after microneedling to enhance absorption. Costs range from about $500 for a combined polynucleotide and microneedling treatment to $900–$1,000 for injections where available.
Salmon DNA is well tolerated by the human body due to its similarity to human DNA, and the testes are used for extraction because they contain a high concentration of DNA, making the process more cost-efficient. Side effects are generally mild, including bruising and inflammation from injections, or swelling and redness from microneedling.
Results vary among individuals. A 2024 review of polynucleotide use in aesthetic medicine found some studies showing significant improvements in skin elasticity and hydration, while others reported limited or no benefits. Dr Lauren Taglia, a dermatologist, says more research is needed before she recommends the treatment. According to Westreich, results typically last six to nine months, with most people seeing some improvement.
