Pharmacist Dr Philip Crilly has highlighted a rare but potentially serious side effect of the cholesterol-lowering medicine atorvastatin that he says is not often discussed. While muscle aches are a recognised possible side effect, liver problems can also occur in people taking statins, although serious complications are rare.
Warning signs to look out for
In a TikTok video, Dr Crilly explained that symptoms of liver problems include yellowing of the skin and the whites of the eyes, or unusually dark urine. He said: "Most people know about the muscle problems with statins but there's another side effect I don't talk about nearly as often. Liver problems. They're rare but they can be serious. Things to look out for include yellowing of your skin and the whites of your eyes or unusually dark urine."
The NHS confirms that atorvastatin can rarely cause liver inflammation, which may lead to yellowing of the skin or the whites of the eyes. Other warning signs can include pale stools, and anyone who notices these symptoms while taking the medicine should seek urgent medical advice.
How pharmacists discuss side effects
Dr Crilly also reflected on how pharmacists discuss potential side effects with patients, saying: "If I'm talking to somebody taking a statin, the serious side effect I'd most likely emphasise is the muscle pain and weakness." He added that counselling should focus on making sure people understand the symptoms that matter, rather than simply giving them a long list of possible reactions.
Muscle pain, tenderness or weakness that cannot be explained by exercise can also require prompt medical attention, particularly if accompanied by feeling unwell or dark, reddish-brown urine. The NHS advises people who think they may be experiencing a serious side effect from atorvastatin to contact NHS 111.
What patients should do
People taking the medicine should not stop or change their dose simply because they are worried about a possible side effect. Instead, they should seek advice from a doctor or pharmacist, who can assess their symptoms and advise on the safest next step.
Atorvastatin remains an important treatment for people who need help managing cholesterol and reducing cardiovascular risk. Knowing the warning signs does not mean a serious problem is likely, but recognising them early can help people get the right care.
