Dr Amir Khan has addressed a common concern among users of GLP-1 injections: why weight loss may appear to have plateaued. The doctor, known for his appearances on ITV, says this is the "most common" query he receives from patients.
What Are GLP-1 Injections?
GLP-1 (glucagon-like peptide-1) is a naturally occurring gut hormone that regulates blood sugar levels and appetite. GLP-1 receptor agonists, such as Mounjaro, have become popular for their effectiveness in controlling blood sugar in diabetics and aiding weight loss. These injections work by suppressing appetite, leading to reduced calorie intake.
Why Weight Loss Slows Down
In a video shared on his Instagram profile, Dr Amir explained that initial rapid weight loss often gives way to a plateau. He stated: "When you first start these medications, they slow down how quickly food leaves your stomach, reduce appetite, help you feel fuller for longer, and dampen food cravings. So initially, many people eat less without feeling like they're dieting, and the weight comes off."
However, the body adapts. Dr Amir added: "Your body is incredibly smart and doesn't particularly like losing weight. From an evolutionary perspective, weight loss can look like starvation. So as you lose weight, your body fights back. Your metabolism slows down slightly, you burn fewer calories because you're carrying less body mass. Hunger hormones creep up, and the body becomes more efficient with calories. The gap between calories eaten and burned becomes smaller, leading to a plateau."
Adjusting Dosage
Dr Amir noted that some individuals may require a higher dose to overcome biological resistance. "The higher dose can provide a stronger appetite-suppressing effect and help overcome some of those biological resistance mechanisms. But even then, weight loss often slows or plateaus, and that's completely normal."
Shifting to Maintenance
He advised patients to view plateaus as a transition from rapid weight loss to weight maintenance. "Think of it this way: you've moved from the rapid weight loss phase into the weight maintenance phase. For many people, staying the same weight after losing a significant amount is a really good success. The medication may still be preventing weight regain even if the scales aren't moving."
Dr Amir's key advice: "If you've hit a plateau, don't panic. It doesn't necessarily mean the drug has stopped working. It often means your body has adapted to a new weight, and the battle has shifted from losing weight to keeping it off." He recommends consulting a GP if concerns persist.
