Millions of people in the UK taking medication for high blood pressure have been alerted to potential side effects by Dr Amir Khan. The NHS GP and ITV doctor specifically highlighted issues linked to ramipril and amlodipine, two widely prescribed drugs for hypertension and cardiovascular health.
Social media alert
In a video posted on Instagram, taken from his appearance on ITV's Lorraine, Dr Khan warned: "If you're on blood pressure tablets: watch this." He acknowledged that these medications are vital and life-saving but noted that common side effects often lead patients to either endure discomfort or stop treatment without medical guidance.
He added: "Common blood pressure tablets like ramipril and amlodipine do have side effects, which either mean people suffer in silence or stop taking them altogether." He stressed that patients should not give up on treatment, as numerous alternatives exist.
Ramipril and dry cough
Dr Khan explained that ramipril works by altering kidney enzymes to reduce blood pressure, which can release bradykinin, a substance causing airway irritation and a persistent dry cough. He pointed out that many patients undergo unnecessary chest X-rays or antibiotic courses when the real culprit is their medication.
"Lots of people get put on antibiotics and get sent for chest X-rays, and nothing gets found," he said. "It's the ramipril. There are lots of alternatives."
Amlodipine and swollen ankles
Focusing on amlodipine, he described how the drug dilates blood vessels, sometimes causing fluid to leak into the lower extremities, resulting in swollen ankles. This side effect affects approximately 20% of users.
Dr Khan urged anyone experiencing these symptoms—swollen ankles or a dry cough—to consult their physician rather than suffering in silence, as effective alternatives are available.
Supply chain issues
This guidance follows recent disruptions in the supply chain. The UK Department of Health and Social Care has extended the Serious Shortage Protocol (SSP087) for ramipril 1.25mg capsules until October 30, 2026, due to ongoing supply challenges. Pharmacists can limit prescriptions to a one-month supply, even if the prescription indicates a longer period.
The shortage mainly affects the 1.25mg capsules. Other forms and strengths might be available but cannot meet total demand. A separate Class 2 recall affected a batch of 10mg capsules earlier due to packaging errors.
Patients are advised not to stop taking their medication without consulting a healthcare professional. Anyone experiencing unexpected symptoms or struggling to fulfil prescriptions should contact their GP or local pharmacist immediately.
