Grace Van Patten stars as Amanda Knox in The Twisted Tale of Amanda Knox, a compelling drama that arrived on ITV on Friday, July 17, 2026. The series explores the extraordinary real-life case of Knox, who was convicted and later acquitted for the 2007 murder of her roommate, Meredith Kercher, in Perugia, Italy.
Background of the Deal Between Disney+ and ITV
The series was originally released on Disney+ in 2025 as part of a landmark partnership between The Walt Disney Company and ITV. The deal, described as a 'new first-of-its-kind initiative,' allows ITVX to carry Disney+ content, while ITV's free streaming service ITV+ offers a 'Taste of Disney+' section. This arrangement was designed to 'expand viewer choice and celebrate the best of British and international storytelling,' according to the companies. Fans have enjoyed access to prestige series like FX's The Bear, Star Wars prequel Andor, and comedy Only Murders in the Building without needing a separate Disney+ subscription.
What Is The Twisted Tale of Amanda Knox About?
The series follows Knox's journey to clear her name after being convicted for the November 2007 murder of her roommate, Meredith Kercher, in Perugia, Italy. Knox was sentenced to 26 years in prison in 2009 but was released and had her conviction overturned two years later. She was convicted of murder for a second time in 2014 before the Italian Supreme Court of Cassation definitively acquitted her of Kercher's murder in 2015. Rudy Guede was ultimately convicted for the murder and remains behind bars. The series is based on Knox's memoir, Waiting to Be Heard, which details the events from 2007 to 2022, including her trial, conviction, and exoneration.
Full Cast of The Twisted Tale of Amanda Knox
- Grace Van Patten as Amanda Knox
- Sharon Horgan as Edda Mellas
- Francesco Acquaroli as Giuliano Mignini
- Giuseppe De Domenico as Raffaele Sollecito
- John Hoogenakker as Curt Knox
- Roberta Mattei as Valentina Greco
- Stefano Cassetti as Carlo Dalla Vedova
- Joe Lanza as Chris Mellas
- Alfredo Pea as Don Saulo Scarabattoli
- Corinna Bennati Lo Castro as Ginevra Ferrari
- Anna Van Patten as Deanna Knox
- Rhianne Barreto as Meredith Kercher
- Vincenzo Zampa as Tommaso Conti
- Lorenzo Cingolani as Luca Altieri
- Evelyn Famà as Lucrezia Ippolito
- Angelo Libri as Luca Lilli
- Fabio Salerno as Bruno Ricci
- Crosby Fitzgerald as Madison
- Uta Dunz as Oma
- Rebecca Hazlewood as Stephanie Kercher
- Rebecca Wisocky as Cecilia
- Antonio Rampino as Francesco Sollecito
Where Have You Seen the Cast Before?
Grace Van Patten, who plays the lead role, made her acting debut at age eight on The Sopranos in an episode directed by her father. She later starred in the Netflix romantic comedy Tramps (2016) and appeared in films such as The Meyerowitz Stories (New and Selected), The Wilde Wedding, and Under the Silver Lake. She was also reportedly one of the actresses who auditioned for the role of Wonder Woman in the upcoming 2027 Superman sequel Man of Tomorrow.
Sharon Horgan, who plays Amanda's mother Edda Mellas, is an Irish actress known for creating and starring in Catastrophe, Bad Sisters, and Motherland for the BBC. Her recent Hollywood roles include Game Night, Military Wives, Together, Everybody's Talking About Jamie, and The Unbearable Weight of Massive Talent, where she played Nicolas Cage's ex-wife.
Other notable cast members include Francesco Acquaroli (Fargo), John Hoogenakker (One Battle After Another), Anna Van Patten (Euphoria), Rhianne Barreto (The Outlaws), Evelyn Famà (Cyrano), Crosby Fitzgerald (Little House on the Prairie), Rebecca Hazlewood (The Good Place), and Rebecca Wisocky (American Horror Story).
