A study published in PLOS One has found that higher levels of vitamin C in the blood are associated with better brain health in older adults. Researchers analysed data from 2,044 Japanese adults aged over 64 and discovered that those with lower plasma vitamin C concentrations had reduced grey matter volume and weaker connectivity within the default mode network, a brain system crucial for memory and attention.
Study Details and Methodology
Scientists used MRI scans to measure grey and white matter volumes, and assessed functional connectivity within the default mode network. They controlled for factors such as age, education, and physical activity. The results showed a consistent pattern: lower vitamin C levels correlated with diminished brain structure and network integrity.
Implications for Cognitive Health
While the study does not prove causation, it adds to evidence that nutrition plays a key role in preserving cognitive function during ageing. Study author Tomohiro Shintaku stated: "Our study demonstrates that higher plasma vitamin C levels are associated with better preserved structural connectivity of the default mode network... This finding generates the exciting hypothesis that a diet rich in vitamin C might play a supportive role in maintaining brain health."
Expert Commentary
Shintaku added: "What I found most fascinating about this research is that we were able to detect these subtle but significant associations between a single nutritional factor and large-scale brain networks by utilising a robust, community-based cohort of over 2,000 older adults." However, researchers caution that further studies are needed to understand the biological mechanisms behind the link.
Sources of Vitamin C
Good dietary sources of vitamin C include citrus fruits (oranges, orange juice), peppers, strawberries, blackcurrants, broccoli, Brussels sprouts, and potatoes.
