PDRN, short for polydeoxyribonucleotide and commonly known as 'salmon DNA', is trending in skincare, with thousands of TikTok posts. Originally developed for medical wound healing, it is now a key ingredient in 2026, praised for supporting skin repair, hydration and barrier strength.
Dermatologists describe PDRN as a 'long-game' ingredient that encourages the skin to repair itself more efficiently by stimulating fibroblast activity, which produces collagen and elastin. It can be used morning or evening after cleansing but before moisturising, and is gentle enough for most skin types.
For improved hydration and barrier resilience without irritation, a purse-friendly option is the PDRN Serum from Boots, priced at £8. Lightweight and non-sticky, it layers well under SPF and makeup, making it an easy entry point into recovery-first skincare.
For retinol users, Dr Ewa Kania recommends the Anua PDRN Hyaluronic Acid Capsule 100 Serum, combining PDRN with hyaluronic acid to deliver hydration while supporting barrier repair, particularly helpful for sensitised skin from retinol use.
PDRN also fits naturally into post-procedure routines. The Dr Reju-All Advanced PDRN Rejuvenating Cream, £32.89 at Superdrug, is designed for oily, dry and combination skin types, helping the skin recover from daily environmental stress while restoring hydration, glow and firmness overnight.
A viral favourite is the Medicube PDRN Pink Peptide Serum, stocked at Boots. It combines PDRN with peptides for a plumper, more radiant look over time. However, as with any new product, a patch test is recommended, especially for those with fish allergies, as most PDRN is derived from salmon DNA.
