The NHS has issued a warning to patients taking the widely prescribed blood pressure medication amlodipine, urging them to call 111 if they develop sudden and severe tummy pain, which could signal acute pancreatitis—a rare but serious side effect.
What Is Amlodipine and How Does It Work?
Amlodipine is a prescription drug used to treat high blood pressure (hypertension) and angina (chest pain). It works by relaxing and widening blood vessels, allowing blood to flow more easily throughout the body. While effective, like all medications, it can cause side effects, though not everyone experiences them.
Serious Side Effects: Acute Pancreatitis
The NHS website warns that some side effects are “serious” yet “rare.” One such reaction is acute pancreatitis, an inflammation of the pancreas that triggers sudden and severe abdominal pain that does not go away. Other symptoms may include a high temperature, nausea, or vomiting.
The abdominal pain associated with acute pancreatitis can:
- Start suddenly and persist
- Be severe, sharp, or knife-like
- Affect the upper part of the tummy (between the ribs), one side, or the entire tummy
- Spread to the sides and back
- Feel worse after eating, moving, or lying down
- Feel better when leaning forward or bringing knees to the chest (fetal position)
If you experience these symptoms, the NHS advises calling 111 immediately.
Other Rare but Serious Side Effects
In addition to pancreatitis, amlodipine can cause other serious side effects, including:
- An allergic reaction (anaphylaxis) – symptoms include a swollen throat or tongue, raised itchy rash, and difficulty breathing
- Stevens-Johnson syndrome – a serious skin reaction causing blistering, painful sores, skin peeling, and flu-like symptoms
The NHS also notes: “Though it is very rare, amlodipine can cause heart attacks.” Patients are told to call NHS 111 if they think they might be experiencing serious side effects.
Common but Less Serious Side Effects
More common side effects of amlodipine include:
- Swelling in the ankles, feet, and legs (oedema)
- Headaches, dizziness, and feeling sleepy
- A fast heartbeat or noticeable heartbeats (palpitations)
- A red and warm face or neck (flushing)
- Tummy pain and nausea
- Constipation or diarrhoea
- Feeling weak and tired (fatigue)
The NHS advises: “If you feel dizzy or sleepy after taking amlodipine, do not drive, ride a bike or use machinery until you no longer have these symptoms.” Patients should speak to a pharmacist or doctor if they have side effects that bother them or do not go away.
