Paracetamol is the world's most popular painkiller, available over the counter and on prescription. Unlike ibuprofen or aspirin, it does not cause stomach bleeding, and unlike opioids such as codeine, it avoids addiction and constipation. However, a 2015 study raised concerns about long-term use.
The study, a systematic review, analysed data from various groups, including kidney patients and those taking paracetamol alongside ibuprofen. It suggested an increased risk of heart attacks, stroke, and early death in long-term users. But the findings are not definitive, as the data came from diverse populations and some participants took other drugs known to cause similar side effects.
Importantly, the study focused on heavy users—those taking around 15 tablets per week over many years. For occasional users, there is no cause for alarm, provided daily limits are respected to avoid overdose risks.
If you are a long-term, high-dose user, it is advisable to discuss alternatives with your doctor. Overall, paracetamol remains safe for short-term, occasional use when taken as directed.
