A new study has revealed that lung cancer tumours can 'feed' off sugar, with researchers identifying a molecule called glycogen as a key driver of tumour growth. The findings suggest that diet, particularly a Western diet high in fat and fructose, may play a significant role in lung cancer progression.
Scientists at the University of Florida observed that lung tumours grew larger and more aggressive in mice fed a diet high in fat and fructose, a common sugar in processed foods. Conversely, reducing glycogen levels led to decreased tumour growth, highlighting the molecule's central role in cancer development.
Lead researcher Ramon Sun, PhD, described glycogen as an 'exceptionally good predictor' of tumour growth and mortality in lung cancer patients. He noted that lung cancer is not traditionally linked to diet, unlike pancreatic or liver cancer, but this study marks a significant shift in understanding.
The research, published in Nature Metabolism, builds on decades of work on Lafora disease, a rare neurological condition. The team found that targeting glycogen could open new treatment avenues, with three existing medications already known to influence glycogen levels.
Professor Matthew Gentry emphasised the importance of diet and lifestyle in cancer prevention, saying: 'Fostering better dietary habits can be a powerful tool in lung cancer prevention.' The study underscores the need for public awareness and policy-driven strategies similar to anti-smoking campaigns.
