A major new study has found no evidence that taking paracetamol during pregnancy increases the risk of autism, ADHD, or intellectual disability in children. The research, published in the Lancet Obstetrics, Gynaecology and Women’s Health, is described as a 'gold standard' review of 43 previous studies.
The findings directly contradict claims made by US President Donald Trump in September, when he urged pregnant women to avoid taking paracetamol, citing unsubstantiated links to autism. The study's authors, led by Professor Asma Khalil of City St George’s, University of London, say their analysis is the most rigorous to date.
Professor Khalil said: 'The message is clear: paracetamol remains a safe option during pregnancy when taken as guided. This is important as paracetamol is the first-line medication we recommend for pregnant women in pain or with a fever.' The researchers hope the review will end scepticism about using the drug during pregnancy.
The study examined data from over 260,000 children assessed for autism, 335,000 for ADHD, and 406,000 for intellectual disability. It concluded that familial and genetic factors are more plausible explanations for any previously observed associations than paracetamol itself.
Health Secretary Wes Streeting had previously advised UK women to ignore Trump's remarks. Experts have welcomed the study, with Professor Grainne McAlonan of King’s College London saying she hopes it 'brings the matter to a close'.
