Researchers in Taiwan have discovered that a combination of three dietary supplements can reverse autism-like symptoms in mice, raising hopes for a potential treatment in humans. The study, published in the journal Plos Biology, found that a 'cocktail' of zinc, serine, and branched-chain amino acids (BCAAs) improved social behaviours and neuronal connectivity in the animals.
Autism spectrum disorder (ASD) affects approximately one in every 100 children in the UK. It is characterised by difficulties in communication and social interaction, as well as sensory sensitivities. Currently, there is no cure, and treatments focus on managing symptoms through therapy and medication.
The team from Academia Sinica in Taiwan tested the supplement mixture on autistic mice. After just seven days, they observed significant changes in brain activity and behaviour. 'I was thrilled to observe that just seven days of treatment with the nutrient mixture significantly modulated neuronal circuit activity and connectivity in real time,' said co-first author Ming-Hui Lin.
Individually, the supplements had no effect, but together they calmed overactive neurons and improved social behaviour. 'Our findings show that a low-dose nutrient mixture containing zinc, branched-chain amino acids and serine offers a safe and more practical strategy for long-term, broad application, even beginning in childhood,' said author Yi-Ping Hsueh.
The researchers believe the findings mark a promising new avenue for dietary therapy in autism. However, further studies are needed to confirm whether the same effects occur in humans.
