Wes Streeting has warned that the Labour Government is losing the battle against nationalism and must alter its approach, or risk handing Downing Street to Reform UK.
Delivering his resignation speech in the House of Commons on Wednesday, the former health secretary called on Prime Minister Sir Keir Starmer to step down, having quit the cabinet last week.
Mr Streeting stated: "I left the Government because we are in the fight of our lives against nationalism, and it is a fight that we are currently losing."
He added: "Unless we change course, we risk handing the keys of No 10 to Reform, and I do not want that on our consciences."
Highlighting the spread of nationalist movements, he said: "For the first time in our history, nationalists are in power in every corner of the United Kingdom. Scottish and Welsh nationalism represents an existential threat to the future integrity of the United Kingdom. And Reform UK represent a threat to the values and ideals that have made this country great."
Mr Streeting also told MPs that he does not believe Labour has "time to waste in Government treading water", but expressed optimism: "The Labour Party was elected to deliver real change. We still can."
His criticism piles pressure on Sir Keir's premiership, which faces a potential challenge from Andy Burnham if the Greater Manchester mayor succeeds in his bid to return to Westminster. Mr Burnham has been confirmed as Labour's candidate for the upcoming Makerfield by-election.
Mr Streeting has made clear he intends to stand in any leadership contest. However, the Prime Minister has insisted he will not "walk away" from Downing Street.
