Millions of people in the UK rely on antihistamines to manage hay fever and other allergies. However, Dr Punam Krishan, an NHS GP appearing on BBC's Morning Live, has warned that many may be using them incorrectly and urged patients not to discontinue their medication based on misleading headlines.
Antihistamines and Weight Gain: What the Evidence Says
Dr Punam addressed concerns that antihistamines could cause weight gain. While histamine influences hunger and energy levels, she stated that weight gain is not a common or listed side effect, especially for newer non-drowsy antihistamines. She emphasized, "I don't want anyone panicking. I don't want anyone stopping their antihistamines." If patients notice increased hunger or fatigue, she advises consulting a GP to explore alternative options.
Correct Usage of Antihistamines
Dr Punam highlighted the importance of timing and consistency. For seasonal allergies, she recommends starting medication early, even before symptoms appear. She also dispelled the myth of building tolerance, reassuring that antihistamines remain effective year after year. Conversely, stopping medication abruptly can lead to rebound symptoms.
The Fruit Juice Warning
A lesser-known fact involves the antihistamine fexofenadine. Dr Punam explained that certain fruit juices—orange, grapefruit, and apple—can block its absorption by up to 70%. She advises taking fexofenadine with water and avoiding these juices for several hours before and after. The NHS website echoes this warning.
Alcohol Interactions
Combining antihistamines with alcohol can increase drowsiness and impair alertness. Dr Punam cautioned, "Alcohol is a sedative. If you're combining that with antihistamines, it can potentially make you feel more drowsy."
Dr Punam encourages patients to find the antihistamine that works best for them and to stick with it. The NHS website provides a lookup tool for more information on different medications.



