James Buckley's wife, Clair, has revealed that her husband reduced his alcohol consumption after learning he has a genetic predisposition to cardiovascular problems. The Inbetweeners star, 38, has high levels of lipoprotein(a), an inherited type of fat and protein in the liver.
Health Scare and Diagnosis
According to cholesterol charity HEART UK, high levels of lipoprotein(a) can cause it to stick to artery walls and clog them, potentially leading to heart disease and stroke at a young age. Buckley discovered his high levels during a health check while Clair was in hospital being treated for severe dehydration.
Speaking on The Chris Moyles Show on Radio X, Clair said the actor “still drinks” but cut back for his health. She explained that his mother had messaged him about having the genetic condition, urging him to get checked. After testing, they confirmed he had it and advised him to “be a bit healthier”.
Lifestyle Changes and Podcast Revelations
On the couple's podcast, At Home With The Buckleys, James said a blood test sparked concern, leading to further tests. Clair described her hospital stay, saying: “I got a little virus and it just apparently dehydrated me beyond belief. And I didn’t really know until it was time to go to hospital.” She added: “I’m all good now. I’ve been on the electrolytes for weeks now.”
Buckley spoke about his condition on the podcast, saying: “There’s nothing you can do about it. And the doctor’s just been like, ‘you need to change’. My heart, my arteries. I’m not a religious man, but sometimes I feel like there is a God that sort of goes ‘that’ll teach you’.”
Prevalence and Management
High lipoprotein(a) levels are common, affecting about 20% of people worldwide, according to the Cleveland Clinic. Because they are genetically determined, levels do not change over a lifetime. HEART UK recommends managing overall risk of heart disease and stroke, aiming for a non-HDL cholesterol level below 2.5mmol/L and/or LDL cholesterol below 1.8mmol/L.
Buckley portrayed Jay Cartwright in The Inbetweeners and its two film adaptations, released in 2011 and 2014. His most recent role was in the 2026 film Mother’s Pride with Martin Clunes.
