Police have closed the A4061 Rhigos Road in both directions following a serious collision on Rhigos Mountain.
The closure is in place on the mountain route between Hirwaun and Treherbert and is expected to remain in force for some time.
Motorists advised to avoid area
Motorists are being advised to avoid the area and use alternative routes where possible, with delays expected in the surrounding area.
Police are currently at the scene of the incident.
Live updates
Updates are being provided as the situation develops.